Mountain center located at 900 meters. s.l.m., on the western side of the Maiella in the upper valley of the Orta river, bounded behind, on the eastern side by the highest peaks of the Maiella massif (Monte Amaro m. 2793, I Tre Portoni m. 2653, Il Pesco Falcone m. 2646, Monte Rapina m. 2023 and further east the Monte Acqua Viva m. 2737) and from the western side beyond the course of the river Orta from the peaks of Monte Morrone (m. 2061), Monte Mileto (m. 1920), Monte La Mucchia (m. 1985).

Bordering the municipalities of Caramanico Terme, Fara S. Martino, Pacentro and Sulmona, it occupies the extreme southern edge of the province of Pescara, with a total extension of 40 km² and extends entirely in the Maiella National Park. S. Eufemia, a village of 269 inhabitants, is located on undulating terrain and has a non-homogeneous territorial system, including the Lama Bianca Nature Reserve and bordering the Orfento Valley Reserve. The oldest evidence is reported in the Chronicon casauriense and is the act by which Bernard, in September 1064, gives the church of S. Eufemia located in the valley of Caramanico, to the monastery of S. Clemente in Casauria. Gathered in family groups, the settlers of the monastery gave birth to nuclei called "Villas" starting the construction of farmhouses and farms: Villa S. Eufemia, Villa Ricciardi and Villa S. Giacomo.

In 1306 St. Euphemia is mentioned in the Acts of the process of canonization of Friar Pietro del Morrone, former Pontiff with the name of Celestine V, since many people of the house of St. Euphemia testified in favor of his holiness. The history of S. Eufemia is linked to that of Caramanico since the Middle Ages, it depended on it for trade and administration, but there are also news dating back to 1145 year when it was a fief of Boamondo count of Manoppello. In this same century the Count of Minervino, Giacomo Arcucci, acquired the feudal rights to S. Eufemia and Roccacaramanico from Queen Giovanna. With the death of Arcucci in 1389, the D'Aquino arrived in Caramanico. In 1505 Ferdinando III the Catholic assigned the feud to Prospero Colonna and the D'Aquino returned.

In 1576, Father Serafino Razzi wrote about his stay in the Villa of S. Eufemia: "On the 8th of April, Sunday in passion, after I had preached in Caramanico, prayed, I went two miles higher to a Villa of a hundred fires, called Santa Eufemia, with horse and boy. Where I gave two sermons: one after Vespers, and the other after Compline, in a very understanding church, full of most women: since their husbands, almost all as pastors that he is, are the vernata with their flocks in Puglia. They are the inhabitants of this villa very proud and reverent of the holy Priests. I founded the sacred company of the Most Holy Name of God. And two years before we had founded that of the Holy Rosary Fr. Master Paolino Bernardini from Lucca, who preached that year he still in this land. I observed how they covered their houses, mostly with beech planks, loaded, by reason of the winds, with large and heavy stones. And these say to do, because the wintering must be that several times a day climb over their roofs to shovel, and throw down the snow. The danger is not in the tables, which are placed one over the other in the form of tiles, and hold the water, and do not break so easily. And when such tables in heads become fracid years, the abundant forests nearby give others. He keeps this villa beautiful blood, nor wants to get married with the Caramanic people instead of ugly appearance".

In 1636, mistress of the lands of S. Eufemia was the princess of Stigliano, who was succeeded by Castruccio da Caramanico. In 1640, Anna Caraffa, princess of Stigliano, sold Caramanico and his villas to Bartolomeo D'Aquino, to whom they remained until 1806, when most of the towns of the Kingdom of Naples were freed from feudalism. S. Eufemia remained a fraction of Caramanico and only on 8 March 1842, by royal decree, became an autonomous municipality. Later, by Royal Decree No. 1140 of 22.01.1863, it was renamed S. Eufemia a Maiella. In 1864 it gained municipal autonomy by incorporating Villa Ricciardi and S. Giacomo. Following the Unification of Italy S. Eufemia and the entire district knew the phenomenon of brigandage, in particular for the actions of the brigand Angelo Colafella, a native of the country.

On 1 January 1930 the municipality of Roccacaramanico was merged with that of S. Eufemia, becoming a fraction. During World War II St. Euphemia in Maiella was subjected to German occupation and her population had to be displaced until the spring of 1944. After the war, if emigration hit the country significantly reducing its population, since the 70s the country discovers and enhances its tourist vocation becoming a place of vacation and stay.